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Which of the following should take place during periodic site visits?

  1. Finalization of the study report

  2. Submission of study findings to the FDA

  3. Identification of protocol violations

  4. Completion of the CRF data entry

The correct answer is: Identification of protocol violations

During periodic site visits, the main focus should be on identifying any protocol violations. This involves reviewing the study procedures and ensuring that they are being followed correctly by all participants. Option A, finalization of the study report, is not appropriate for periodic site visits as it is typically done after the study is completed. Option B, submission of study findings to the FDA, is also not appropriate as this is typically done once all data is collected and analyzed. Option D, completion of the CRF data entry, is not the primary purpose of periodic site visits as it can be done at any time during the study. Therefore, the best and most important action to take during periodic site visits is to identify potential protocol violations.