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Which of the following is NOT a main category covered by ICH guidelines?

  1. Quality topics

  2. Safety topics

  3. Regulatory topics

  4. Multidisciplinary topics

The correct answer is: Regulatory topics

ICH guidelines cover a wide range of topics related to the development and manufacturing of pharmaceuticals. Quality, safety, and multidisciplinary topics are all areas that are addressed by ICH guidelines. Regulatory topics are not one of the main categories covered, as they typically fall under the umbrella of safety or quality. Overall, ICH guidelines are comprehensive and cover critical aspects of the pharmaceutical industry.