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Which of the following best describes when the majority of CRF data are verified against source record information?

  1. Before the study begins

  2. During the study's conclusion

  3. Periodic site visits

  4. After submitting the final report

The correct answer is: Periodic site visits

CRF data verification against source record information typically occurs during periodic site visits. Option A, before the study begins, is incorrect because the data has not yet been collected. Option B, during the study's conclusion, is incorrect because it is too late to make necessary corrections to the data. Option D, after submitting the final report, is incorrect because the study has already been completed and the data has been submitted. The best time to verify CRF data against source record information is during periodic site visits to ensure the most accurate and up-to-date data is being collected.