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When is the investigator required to update the IRB about the study's progress?

  1. During the conduct of the study and at termination

  2. During the conduct of the study only

  3. Never

  4. At study termination only

The correct answer is: During the conduct of the study and at termination

During the conduct of the study, the investigator is required to update the IRB periodically on the progress of the study. This allows the IRB to ensure the study is being conducted ethically and safely for participants. At termination of the study, the investigator must also provide a final update to the IRB. Option B is incorrect because it does not mention the final update required at termination. Option C is incorrect because the IRB must be updated during the study. Option D is incorrect because the IRB must also be updated during the study.