CITI Training Practice Exam

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What should an investigator do if a new drug becomes available that might benefit a study subject?

  1. Automatically switch the subject to the new drug

  2. Ignore the new drug to avoid bias

  3. Discuss the pros and cons of both drugs and let the subject decide

  4. Exclude the subject from the study

The correct answer is: Discuss the pros and cons of both drugs and let the subject decide

An investigator should not automatically switch the subject to the new drug because it can introduce bias and affect the results of the study. Ignoring the new drug is also not the best option as it may deny the subject a potentially beneficial treatment option. Excluding the subject from the study is not necessary unless it is a requirement for the study or if the subject no longer meets the study criteria. The best course of action is to discuss the pros and cons of both drugs and let the subject decide, as it ensures informed consent and respects the subject's autonomy.

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