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The packaging of investigational drugs should ideally:

  1. Look like a marketed product

  2. Allow subjects to identify placebo pills

  3. Be designed to help with subject compliance

  4. Be attractive to study coordinators

The correct answer is: Be designed to help with subject compliance

Ideally, the packaging of investigational drugs should be designed to help with subject compliance. This means that the packaging should be user-friendly and make it easy for study participants to accurately take the medication as prescribed. Options A and D are incorrect because the packaging of investigational drugs should not be misleading or attractive in the same way that marketed products are, as this could potentially influence the participants' perception of the medication's effectiveness. Option B is incorrect because having placebo pills easily identifiable could bias the subjects' responses and compromise the integrity of the study. Thus, the best option is to prioritize packaging that aids in subject compliance.